Uveitis in Juvenile Idiopathic Arthritis

PurposeTo assess the long-term outcome of uveitis in juvenile idiopathic arthritis (JIA).DesignPopulation-based, multicenter, prospective JIA cohort, with a cross-sectional assessment JIA-associated (JIA-U) 18 years after onset JIA.ParticipantsA total 434 patients JIA, whom 96 had uveitis, from defined geographic areas Denmark, Finland, Norway, and Sweden.MethodsPatients between January 1997 June 2000 were prospectively followed for years. Pediatric rheumatologists ophthalmologists collected clinical laboratory data.Main Outcome MeasuresCumulative incidence characteristics, disease activity, ocular complications, visual outcome, risk factors associated development uveitis-related complications.ResultsUveitis developed (22.1%) JIA. In 12 (2.8%), was diagnosed 8 follow-up. Systemic immunosuppressive medication more common among (47/96 [49.0%]) compared without (78/338 [23.1%]). Active present 19 78 (24.4%) at 18-year visit. Ocular complications occurred 31 80 (38.8%). Short duration diagnosis factor developing (odds ratio [OR], 1.4; 95% confidence interval [CI], 1.1–1.8). Patients before all cataract an OR glaucoma 31.5 (95% CI, 3.6–274). Presence antinuclear antibodies (ANAs) also 1 or (OR, 3.0; 1.2–7.7). Decreased acuity (VA) <6/12 found 135 eyes (8.9%) 4 (5.0%) JIA-U binocular decreased VA <6/12.ConclusionsOur results suggest that screening should start immediately when is suspected confirmed be continued than Timely systemic treatment high must considered early course to gain rapid control inflammation. To (JIA). Population-based, A Sweden. data. Cumulative complications. Uveitis <6/12. Our